Isabel Rangel Barón: Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer, Published online: 03 April 2018; doi:10.1038/s41586-018-0018-1

The glycolytic enzyme PFKFB4 directly phosphorylates and regulates binding of the coactivator SRC-3 to ATF4 and thereby increases the transcriptional activity of this complex, leading to increased expression of metabolic genes, and enhancing tumour growth and metastasis.

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