Isabel Rangel Baron: Researchers Point out Cells can Change after Chemotherapy

Researchers from the College Hospital Our Lady of Candelaria, in Tenerife, discovered that some cells, when submitted to chemotherapy, stop growing temporarily in the final phase of cellular division, also known as telophase.

According with a statement from the Health Office, the discovery is about a new behavior from cells treated with radiotherapy and chemotherapy, and that, thus far, had not showed up.

The results will help the scientific community to better understand what happens to healthy cells and cancer cells when they received anti-tumor treatment. The study could open new paths of research to design better, more effective, and with less side effects therapies.

“This study shows that oncology treatments make cells in telophase to go back from their DNA separation. A process considered to be irreversible until now”, said PHD Felix Machin, main researcher and coordinator from the Cancer Group and the Genetic Instability Research Unit of the College Hospital Our Lady of Candelaria.

On this regard, he explained “if these results are proved in the future, and extended to other types of cells, it could make us reconsider the pillars of Cellular Biology.”

This finding, lead by researcher Felix Machin, was published on the latest number of Nature Communications, one of the most prestigious scientific magazines worldwide.

Three Years of Study

The publication detailed the results of three-year project, which, at first, tried to understand a paradox in the regular standard, and to explain why cancer cells are more sensitive to chemotherapy and radiotherapy than the healthy ones.

“This paradox happens at the end of the cellular division cycle, exactly when a cell is about to finish creating a copy of itself”, said Felix Machin.

The Cancer and Genetic Instability Group from the Research Unit of the College Hospital of Our Lady of Candelaria recreated a cellular model with yeast capable of synchronizing in telophase before been submitted to oncology therapies.

Resilience Protects from the Negative Effects of Stress During Pregnancy

A study from the University of Granada (UGR) indicates that resilience, which is a set of resources used to face adversity and stress, protects against side effects from pregnancy stress.

Researchers from the Behavior, Mind, and Brain Research Center, and the Faculty of Psychology, from the same college, analyzed, for the first time, the protective roll of resilience in pregnancy. They studied the psychological state of the mother, and the cortisol levels in the hair, which is a new procedure to analyze objectively the amount of cortisol and hormone stress produced over the last few months of gestation.

A total of 151 pregnant women were studied during the third trimester and after giving birth. Psychological variables related to stress in pregnancy and levels of cortisol in the hair were also used.

When comparing pregnant women with a high level of resilience with pregnant women with a low resilience level, researchers found that more resilient pregnant women perceived themselves as less stressed, they had less worries related to pregnancy, and, overall, a better psychological wellbeing.

Moreover, after giving birth they also felt less symptoms of postpartum depression. The analysis of cortisol showed that more resilient pregnant women also had the lowest levels of stress hormone.

According to the results, it can be concluded that resilience has an important roll in protecting against the negative effects of stress, in both a psychological and a biological level, which can happen during pregnancy and after giving birth

It is important to highlight that the data of the results suggest the protective roll of resilience during pregnancy can have on the baby’s health, said experts.

Nevertheless, researchers pointed out they have not performed tests regarding resilience on children or any other group of people, which leaves an open path for future researches.

Science-Based Satire: American Academy of Pediatrics Releases New Guidelines on Corporal Punishment

In December of last year, the American Academy of Pediatrics updated their policy statement on effective discipline. Did it include an algorithm to help caregivers safely dose corporal punishment? No, that’s actually pretty absurd. Offensive even, if you think about it. Don’t though. Look…a squirrel!

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Isabel Rangel Barón: Moral Injury

Check out this powerful You-tube video

When I see another provider who is burned out, my reaction has always been:

“Get another job.  You have no business doing this kind of work.”

Until I saw this video, I never really considered the concept of moral injury.

If a fellow paramedic hurts his back lifting or wrestling with a patient, I would never thing to say, “Get another job.  You don’t belong in this work work anymore.”

Companies take great precautions to make our work physically safe.  There have been great innovations in stretcher design (when I started we used a two man dead lift), stair chairs, safety nets, and driver safety systems.  And while most services have employee assistance programs, I can’t think of any preventative measure routinely taken in EMS to prevent moral burnout.  Long shifts, holdovers, too few cars on the road, 911s holding, order-ins.

Meat in the seat.

There is always a new hiring class to pick up the fallen stethoscopes and take their places on the front lines.

It is hard to change things overnight.

I am glad there seems to be an awakening ahead.


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