Researchers from the College Hospital Our Lady of Candelaria, in Tenerife, discovered that some cells, when submitted to chemotherapy, stop growing temporarily in the final phase of cellular division, also known as telophase.
According with a statement from the Health Office, the discovery is about a new behavior from cells treated with radiotherapy and chemotherapy, and that, thus far, had not showed up.
The results will help the scientific community to better understand what happens to healthy cells and cancer cells when they received anti-tumor treatment. The study could open new paths of research to design better, more effective, and with less side effects therapies.
“This study shows that oncology treatments make cells in telophase to go back from their DNA separation. A process considered to be irreversible until now”, said PHD Felix Machin, main researcher and coordinator from the Cancer Group and the Genetic Instability Research Unit of the College Hospital Our Lady of Candelaria.
On this regard, he explained “if these results are proved in the future, and extended to other types of cells, it could make us reconsider the pillars of Cellular Biology.”
This finding, lead by researcher Felix Machin, was published on the latest number of Nature Communications, one of the most prestigious scientific magazines worldwide.
Three Years of Study
The publication detailed the results of three-year project, which, at first, tried to understand a paradox in the regular standard, and to explain why cancer cells are more sensitive to chemotherapy and radiotherapy than the healthy ones.
“This paradox happens at the end of the cellular division cycle, exactly when a cell is about to finish creating a copy of itself”, said Felix Machin.
The Cancer and Genetic Instability Group from the Research Unit of the College Hospital of Our Lady of Candelaria recreated a cellular model with yeast capable of synchronizing in telophase before been submitted to oncology therapies.